According to Osho, yes: even a desire-driven quest can culminate in desireless witnessing—when repeated frustration exposes that desire is the very source of anxiety and hell. Seeing this link with total clarity, desire and its journey drop by themselves; not by suppression but by understanding. Brief experiments in desirelessness reveal overflowing bliss, empowering responsibility and the key to sustained awareness.
Chasing wants hurts until you see wanting causes the hurt; then the wanting falls away and calm, clear watching appears.