According to Osho, there is both a resemblance and a gulf: drugs can chemically mimic samadhi, producing a dreamlike, pseudo-ecstasy that soothes hunger for truth but never nourishes it, keeps you asleep, and leads to dependence and crash. True samadhi awakens and nourishes being, arising from meditation and awareness, not chemical coercion; it is reality, not illusion. Therefore drugs are obstacles, not a path, to enlightenment.
Drugs feel like the real thing but are just a dream that keeps you asleep; real samadhi wakes you up and feeds your soul.