According to Osho, yes—despair can lead to moksha-sannyasa, but only when it is total and consciously faced. Complete despair becomes Vishada-Yoga, the first noble truth: clear awareness that life is suffering. From there, one must glimpse the second truth—that freedom is possible—often through a living master. Mere despair paralyses; total despair, plus trust and guidance, ignites the journey from anguish to liberation.
Feeling utterly hopeless can start your path to freedom, but you also need to see that escape is possible—often with a wise teacher’s help.