According to Osho, yes: self-bliss does not depend on the body’s health. When even a taste of inner bliss arises, you see you are not the body; pain may be noticed—even more clearly—but without identification. Like an actor aware of the role, you live fully yet untouched; suffering remains as appearance, while you abide as pure knowing, the witness.
Even if you’re very sick, you can still feel deep happiness by knowing you’re not the body—just the one watching it.